Genome Editing Tools and Gene Drives
«
**Description**
This volume describes genome editing tools (molecular methods for the targeted
alteration of DNA sequences) and gene drives (mechanisms that propagate
specific genes well in excess of the rate expected by chance). True to its
name, it is a very brief but effective treatment of these important topics.
This is a stand-alone paperback book without any supporting website or video
backup. At just 100 pages in length, this book very briefly introduces four
approaches to genome editing and six approaches to implementing gene drives.
The book is divided into 13 chapters that range in length from two to 12 pages.
The book is part of the Pocket Guides to Biomedical Science.
**Purpose**
In the preface, the 13 authors describe their principal motivation for writing
the book as a desire to introduce modern methods of genome editing and gene
drives to African scientists and students. Indeed, all of the authors are
African and are currently affiliated with universities in Zimbabwe. This book
will easily fulfill the goal of helping inform African researchers and
students, but its utility goes well beyond that. This book is broadly useful to
any biology student or researcher new to the fields of genome editing or gene
drives.
**Audience**
While the authors are motivated by a desire to smooth the way for the use of
genomic tools in Africa, their writing is so clear and concise that many
audiences will find the book useful. Undergraduate students will find the
concise descriptions of genomic and gene drives methods useful as they learn
about these approaches. New graduate student researchers and professionals
exploring genomic tools will likewise find the focused writing helpful in
gaining a solid initial understanding of the topics covered. The authors have
written accurately and effectively about their topics and provide practical
examples of applications as well as discussions of the pros and cons of
methods.
**Features**
All chapters in this book are brief. The opening chapter gives a quick
orientation to genome editing. This is followed by five chapters on genome
editing approaches. Descriptions of four genome editing methods, zinc finger
nucleases, TALENs, MegaTALs, and CRISPR, are followed by a chapter that offers
a convenient comparison of the methods. The remaining six chapters describe
various methods for applying gene drives. Each chapter contains a discussion of
applications and describes the pros and cons of the method. The book also
contains a helpful glossary, a long list of references cited, and a good index.
**Assessment**
This is a highly useful book that, in its brief 100 pages, captures the essence
of four contemporary approaches to genome editing and six ways in which methods
of gene drives can be applied to captive and natural populations. The brevity
of this book and its comparative lack of research data set it apart from other
books covering the same topics. This book is for those who are new to genome
editing and gene drives. Without getting bogged down in research details,
readers with a biology background who are unfamiliar with the methods discussed
will come away with a working understanding of the methods and approaches
described.- Mark F. Sanders, PhD (UC Davis College of Biological Sciences)
»
Genome-editing methods are becoming routine tools for molecular and cell biologists. Such tools include ZFNs, CRISPR, megaTALs and TALENs. These tools are revolutionizing the creation of precisely manipulated genomes to modify the characteristics of organisms or cells. Les mer
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Key Features
Extensively reviews the current genome-editing tools and gene drives
Clarifies the targeting mechanisms and specificity of genome-editing tools
Details many different types of natural and synthetic gene drives
Highlights concerns with gene drives and genome-editing tools
Related Titles
Brown, T. A. Genomes 4 (ISBN 978-0-8153-4508-4)
Samuelsson, T. The Human Genome in Health and Disease: A Story in Four Letters (ISBN 978-0-8153-4591-6)
Soh, J., et al. Genome Annotation (ISBN 978-1-4398-4117-4)
Detaljer
- Forlag
- CRC Press
- Innbinding
- Innbundet
- Språk
- Engelsk
- Sider
- 130
- ISBN
- 9780367760663
- Utgivelsesår
- 2021
- Format
- 20 x 13 cm
Anmeldelser
«
**Description**
This volume describes genome editing tools (molecular methods for the targeted
alteration of DNA sequences) and gene drives (mechanisms that propagate
specific genes well in excess of the rate expected by chance). True to its
name, it is a very brief but effective treatment of these important topics.
This is a stand-alone paperback book without any supporting website or video
backup. At just 100 pages in length, this book very briefly introduces four
approaches to genome editing and six approaches to implementing gene drives.
The book is divided into 13 chapters that range in length from two to 12 pages.
The book is part of the Pocket Guides to Biomedical Science.
**Purpose**
In the preface, the 13 authors describe their principal motivation for writing
the book as a desire to introduce modern methods of genome editing and gene
drives to African scientists and students. Indeed, all of the authors are
African and are currently affiliated with universities in Zimbabwe. This book
will easily fulfill the goal of helping inform African researchers and
students, but its utility goes well beyond that. This book is broadly useful to
any biology student or researcher new to the fields of genome editing or gene
drives.
**Audience**
While the authors are motivated by a desire to smooth the way for the use of
genomic tools in Africa, their writing is so clear and concise that many
audiences will find the book useful. Undergraduate students will find the
concise descriptions of genomic and gene drives methods useful as they learn
about these approaches. New graduate student researchers and professionals
exploring genomic tools will likewise find the focused writing helpful in
gaining a solid initial understanding of the topics covered. The authors have
written accurately and effectively about their topics and provide practical
examples of applications as well as discussions of the pros and cons of
methods.
**Features**
All chapters in this book are brief. The opening chapter gives a quick
orientation to genome editing. This is followed by five chapters on genome
editing approaches. Descriptions of four genome editing methods, zinc finger
nucleases, TALENs, MegaTALs, and CRISPR, are followed by a chapter that offers
a convenient comparison of the methods. The remaining six chapters describe
various methods for applying gene drives. Each chapter contains a discussion of
applications and describes the pros and cons of the method. The book also
contains a helpful glossary, a long list of references cited, and a good index.
**Assessment**
This is a highly useful book that, in its brief 100 pages, captures the essence
of four contemporary approaches to genome editing and six ways in which methods
of gene drives can be applied to captive and natural populations. The brevity
of this book and its comparative lack of research data set it apart from other
books covering the same topics. This book is for those who are new to genome
editing and gene drives. Without getting bogged down in research details,
readers with a biology background who are unfamiliar with the methods discussed
will come away with a working understanding of the methods and approaches
described.- Mark F. Sanders, PhD (UC Davis College of Biological Sciences)
»