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Metal Ions in Biochemistry

; Prakash B. Samnani

The second edition of Metal Ions in Biochemistry deals with the multidisciplinary subject of bio-inorganic chemistry, encompassing the disciplines of inorganic chemistry, biochemistry and medicine.


The book deals with the role of metal ions in biochemistry, emphasising that biochemistry is mainly the chemistry of metal-biochemical complexes. Les mer
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Vår pris: 1012,-

(Innbundet) Fri frakt!
Leveringstid: Sendes innen 7 virkedager
På grunn av Brexit-tilpasninger og tiltak for å begrense covid-19 kan det dessverre oppstå forsinket levering.

Om boka

The second edition of Metal Ions in Biochemistry deals with the multidisciplinary subject of bio-inorganic chemistry, encompassing the disciplines of inorganic chemistry, biochemistry and medicine.


The book deals with the role of metal ions in biochemistry, emphasising that biochemistry is mainly the chemistry of metal-biochemical complexes. Hence, the book starts with the structures of biochemicals and the identification of their metal binding sites. Thermodynamic and kinetic properties of the complexes are explained from the point of view of the nature of metal-ligand bonds. Various catalytic and structural roles of metal ions in biochemicals are discussed in detail.


Features








The role of Na+ and K+ in brain chemistry.







The role of zinc insulin in glucose metabolism and its enhancement by vanadium and chromium compounds.







Discussion of the role of zinc signals, zinc fingers and cascade effect in biochemistry.







Haemoglobin synthesis and the role of vitamin B12 in it.







The role of lanthanides in biochemical systems.







A detailed discussion of the role of non-metals in biochemistry, a topic missing in most of the books on bio-inorganic chemistry.





The study of bio-inorganic chemistry makes biochemists rethink the mechanistic pathways of biochemical reactions mediated by metal ions. There is a realisation of the role of metal complexes and inorganic ions as therapeutics such as iron in leukaemia, thalassemia and sickle cell anaemia, iodine in hypothyroidism and zinc, vanadium and chromium in glucose metabolism. The most recent realisation is of the use of zinc in the prevention and treatment of COVID-19.

Fakta

Innholdsfortegnelse

1. Structure of Cells and Introduction to Bioinorganic Chemistry................................................. 1
2. Thermodynamic and Kinetic Properties of Metal Complexes....................................................17


3 Alkali and Alkaline Earth Metal Ions in Biochemical Systems................................................. 63


4. Zinc in Biochemical Systems.......................................................................................................... 83


5. Iron in Biochemical Systems........................................................................................................ 103


6. Copper in Biochemical Systems................................................................................................... 139


7. Cobalt in Vitamin B12 in Biochemical System............................................................................ 157


8. Molybdenum in Nitrogen Fixation in Plants...............................................................................167


9. Magnesium and Manganese in Photosynthesis in Plants...........................................................177


10. Less Common Trace Metal Ions in Biochemical Systems..........................................................187


11. Metal Ion Toxicity in Biochemical Systems................................................................................ 209


12. Metal Complexes in Therapeutics................................................................................................219

Om forfatteren

Pabitra Krishna Bhattacharya retired as Professor and Head, Department of Chemistry, M S University of Baroda, 9m 2001, after serving for thirty four years. Prior to that, he served in Kurukshetra University, University of Rajasthan (Jaipur), and Vikram University (Ujjain). Prof Bhattacharya obtained MSc and PhD degrees from University of Saugor, MP. He was awarded senior fellowship under Fulbright Hayes programme to carry out post doctoral work in Ohio state University Columbus USA during 1976 - 77. He also worked in University of Sheffield UK in 1987 under INSA Royal Society Exchange Programme. Prof Bhattacharya's teaching and research interests involved quantum chemistry, spect