Meny
 
Dermatotoxicology Methods - 
      Francis N. Marzulli

Dermatotoxicology Methods

The Laboratory Worker's Ready Reference

Francis N. Marzulli (Redaktør)

This work presents and evaluates methods employed to identify the potential of certain types of chemicals to adversely affect the skin. A variety of test methods are included such as tests for skin penetration, metabolism, irritation, the skin immune system, photo effects, skin cancer, and topical effects of retinoids and depigmenting chemicals. Les mer
Vår pris
2869,-

(Innbundet) Fri frakt!
Leveringstid: Sendes innen 21 dager

Innbundet
Legg i
Innbundet
Legg i
Vår pris: 2869,-

(Innbundet) Fri frakt!
Leveringstid: Sendes innen 21 dager

This work presents and evaluates methods employed to identify the potential of certain types of chemicals to adversely affect the skin. A variety of test methods are included such as tests for skin penetration, metabolism, irritation, the skin immune system, photo effects, skin cancer, and topical effects of retinoids and depigmenting chemicals. Tests for chemicals that affect the reproductive and nervous system are also included. Both animal and human tests that have been standardised and tests that are under development and employ animal alternatives are addressed in this book. Besides different testing methods, a rationale for accepting non-animal models and a review of some regulatory agency discussions about animal alternative tests are included.
FAKTA
Utgitt:
Forlag: CRC Press
Innbinding: Innbundet
Språk: Engelsk
Sider: 412
ISBN: 9781138416789
Format: 23 x 15 cm
KATEGORIER:

Bla i alle kategorier

VURDERING
Gi vurdering
Les vurderinger

Contributors -- Preface -- Preface to Dermatotoxicology, Fifth Edition -- CHAPTER 1 -- Structure-Activity Relationships in Percutaneous Absorption /Jurij J. Hostynek -- Introduction -- Traditional Assessment of Skin Penetration -- Structure-Activity Approach to Percutaneous Absorption -- Limitations of QSAR -- Conclusions -- References -- CHAPTER 2 -- Methods for in Vitro Percutaneous Absorption /Robert L. Bronaugh -- Introduction -- In Vitro Methodology -- In Vivo and In Vitro Correlations -- Barrier Properties of Skin Constructs -- References -- CHAPTER 3 -- Percutaneous Absorption in Humans /Ronald C. Wester and Howard I. Maibach -- Introduction -- Integrated Dermatopharmacokinetics in Man (Hydroquinone) -- Discussion -- References -- CHAPTER 4 -- Percutaneous Absorption of Hazardous Substances from Soil and Water /Ronald C. Wester and Howard /. Maibach -- Introduction -- Discussion -- Acknowledgment -- References -- CHAPTER 5 -- Isolated Perfused Porcine Skin Flap /Jim E. Riviere -- Introduction -- Overview of Method -- Assessment of Viability -- Percutaneous Absorption -- Dermatopharmacokinetics -- Other Applications -- Discussion -- References -- CHAPTER 6 -- Methods in Physiologically Based Pharmacokinetic Modeling /James N. McDougal -- Introduction -- Why use PB-PK Models? -- When can PB-PK Models be used? -- How do you use PB-PK Models? -- What are the Components of a PB-PK Model? -- How do you develop PB-PK Models? -- Conclusion -- Nomenclature -- References -- CHAPTER 7 -- Methods for In Vitro Skin Metabolism Studies /Robert L. Bronaugh -- Introduction In Vitro Methodology -- Skin Metabolism During Percutaneous Absorption -- References -- CHAPTER 8 -- Developing a Toxicology Evaluation Plan for Transdermal Delivery Systems Mary E. Prevo, Michel Cormier; and James Matriano -- Assessment of Previous Experience -- Transdermal Product Assessment: Issues in Test Selection -- Summary -- References -- CHAPTER 9 -- Animal, Human, and In Vitro Test Methods for Predicting Skin Irritation /Sunita M. Patil, Esther Patrick, and Howard I. Maibach -- Animal Tests for Predicting Skin Irritation -- Human Tests for Predicting Skin Irritation -- In Vitro Skin Irritation Assays: Relevance to Human Skin -- Summary -- References -- CHAPTER 10 -- Structure-Activity Relationships in Contact Sensitization: Classification and Ranking of Allergens /Jurij J. Ho sty nek -- Introduction -- Creating a QSAR Model -- The Classification Model -- The Rank Model -- Conclusion -- References -- CHAPTER 11 -- Test Methods for Allergic Contact Dermatitis in Animals /Georg Klecak -- Introduction -- General Principles -- Split Adjuvant Technique -- Freund's Complete Adjuvant Test -- The Modified Draize Test -- The Buehler Test -- The Open Epicutaneous Test -- Modified Guinea Pig Maximization Test -- The Cumulative Contact Enhancement Test -- The Epicutaneous Maximization Test -- Single Injection Adjuvant Test -- The Tierexperimenteller Nachweis (TINA) Test -- The Footpad Test -- The Guinea Pig Allergy Test Adapted to Cosmetic Ingredients -- The Ear /Flank Test (Stevens Test) -- Conclusions -- References -- CHAPTER 12 -- The Local Lymph Node Assay /Ian Kimber -- Introduction -- Methods -- App

Francis N. Marzulli