This book intends to be a book where researchers, practitioners, and industry representatives can present and discuss ongoing work and latest research results of meaningful contributions. These contributions focus on technologies and emerging topics regarding reliable and innovative solutions applied to the healthcare industry including Big Data and Artificial Intelligence for enhancing human quality of life, as well as related issues and challenges. Moreover, it also intends to cover several dimensions of the original research as regarding to theoretical, methodological, and technological developments, and new applications. The main goal of this book is to contribute to the development of new approaches and reliable enabling technologies in the healthcare industry that will enhance not only human quality of life, but also will lead to healthier, innovative, and secure societies as an all. Researchers, Practitioners, and Industry Representatives of Healthcare Information Systems will benefit from this book.