This book constitutes the refereed proceedings of the 19th IFIP WG 5.1 International Conference, PLM 2022, Grenoble, France, July 10-13, 2022, Revised Selected Papers.The 67 full papers included in this book were carefully reviewed and selected from 94 submissions. They were organized in topical sections as follows: Organisation: Knowledge Management, Business Models, Sustainability, End-to-End PLM, Modelling tools: Model-Based Systems Engineering, Geometric modelling, Maturity models, Digital Chain Process, Transversal Tools: Artificial Intelligence, Advanced Visualization and Interaction, Machine learning, Product development: Design Methods, Building Design, Smart Products, New Product Development, Manufacturing: Sustainable Manufacturing, Lean Manufacturing, Models for Manufacturing.