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Biomarkers of Human Aging

Alexey Moskalev (Redaktør)

Serie: Healthy Ageing and Longevity 10

This book collects and reviews, for the first time, a wide range of advances in the area of human aging biomarkers. This accumulated data allows researchers to assess the rate of aging processes in various organs and systems, and to individually monitor the effectiveness of therapies intended to slow aging. Les mer
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Paperback
Legg i
Vår pris: 1856,-

(Paperback) Fri frakt!
Leveringstid: Sendes innen 21 dager
På grunn av Brexit-tilpasninger og tiltak for å begrense covid-19 kan det dessverre oppstå forsinket levering.

Om boka

This book collects and reviews, for the first time, a wide range of advances in the area of human aging biomarkers. This accumulated data allows researchers to assess the rate of aging processes in various organs and systems, and to individually monitor the effectiveness of therapies intended to slow aging.



In an introductory chapter, the editor defines biomarkers of aging as molecular, cellular and physiological parameters that demonstrate reproducible changes - quantitative or qualitative - with age. The introduction recounts a study which aimed to create a universal model of biological age, whose most predictive parameters were albumin and alkaline phosphatase (indication liver function), glucose (metabolic syndrome), erythrocytes (respiratory function) and urea (renal function).



The book goes on to describe DNA methylation, known as the "epigenetic clock," as currently the most comprehensive predictor of total mortality. It is also useful for predicting mortality from cancer and cardiovascular diseases, and for analyzing the effects of lifestyle factors including diet, exercise, and education.



Individual contributions draw additional insight from research on genetics and epigenetic aging markers, and immunosenescence and inflammaging markers. A concluding chapter outlines the challenge of integrating of biological and clinical markers of aging.



Biomarkers of Human Aging is written for professionals and practitioners engaged in the study of aging, and will be useful to both advanced students and researchers.



Fakta

Innholdsfortegnelse

Chapter 1: Introduction - Alexey Moskalev



Section-1: BIOMARKERS OF AGING AND HEALTH



Chapter 2: Practical Detection of Biological Age: Why it is not a trivial task - Ancha Baranova Tiange Cui, Boris Veytsman



Chapter 3: Biological age is a universal marker of aging, stress, and frailty - Timothy V. Pyrkov, Peter O. Fedichev



Chapter 4: Biomarkers of health and healthy ageing from the outside-in - Jonathan Sholl , Suresh Rattan



Chapter 5: Biomarkers of aging - Yizhen Yan, Yonglin Mu, Weiyang Chen, Jing-Dong J. Han



Chapter 6: Review of molecular and cellular biomarkers of aging - Ilya Solovyev, Mikhail Shaposhnikov, Alexey Moskalev



Section-2: PROTEOMICS AND GLYCOMICS BIOMARKERS OF AGING



Chapter 7: IgG glycans as a biomarker of biological age - Vilaj M, Gudelj I, Trbojevic-Akmacic I, Lauc G, Pezer M



Chapter 8: Oxidatively modified proteins and maintenance systems as biomarkers of aging - Bertrand Friguet, Martin Baraibar



Chapter 9: Is impaired proteodynamics a key to understand the biomarkers of cellular aging? - Jacek M. Witkowski ,Tamas Fulop



Section-3: GENETICS AND EPIGENETICS AGING MARKERS



Chapter 10: Genetic markers of extreme human longevity - Paola Sebastiani, Anastasia Gurinovich, Harold Bae, Thomas T Perls



Chapter 11: Epigenetic biomarkers of aging - Morgan E. Levine



Chapter 12: DNA methylation biomarkers to assess biological age -Dmitiriy Podolskiy, Vadim Gladyshev



Chapter 13: Epigenetics of brain aging: lessons from chemo brain and tumor brain - Anna Kovalchuk, Bryan Kolb, Olga Kovalchuk



Chapter 14: Approaches and methods for variant analysis in a cell - Alexej Abyzov, Flora M. Vaccarino, Alexander E. Urban, Vivekananda Sarangi



Section-4: IMMUNOSENESCENCE AND INFLAMMAGING MARKERS



Chapter 15: Is there any reliable biomarker for immunosenescence and inflammaging? - Tamas Fulop, Alan Cohen, Glenn Wong, Jacek M Witkowski, Anis Larbi.



Chapter 16: Immune parameters associated with mortality in longitudinal studies of very old people can be markedly dissimilar even in apparently similar populations - Graham Pawelec, David Goldeck



Chapter 17: Gut microbiota and aging - Kashtanova DA, Tkacheva ON, Strazhesko ID, Dudinskaya EN, Kotovskaya YuV, Popenko AS, Tyaht AV, Alexeev DG



Section-5: SYSTEMS BIOLOGY OF AGING, BIOLOGICAL AGE AND MORTALITY MARKERS



Chapter 18: Deep integrated bi

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