Biomarkers of Human Aging
Alexey Moskalev (Redaktør)
Serie: Healthy Ageing and Longevity 10
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In an introductory chapter, the editor defines biomarkers of aging as molecular, cellular and physiological parameters that demonstrate reproducible changes - quantitative or qualitative - with age. The introduction recounts a study which aimed to create a universal model of biological age, whose most predictive parameters were albumin and alkaline phosphatase (indication liver function), glucose (metabolic syndrome), erythrocytes (respiratory function) and urea (renal function).
The book goes on to describe DNA methylation, known as the "epigenetic clock," as currently the most comprehensive predictor of total mortality. It is also useful for predicting mortality from cancer and cardiovascular diseases, and for analyzing the effects of lifestyle factors including diet, exercise, and education.
Individual contributions draw additional insight from research on genetics and epigenetic aging markers, and immunosenescence and inflammaging markers. A concluding chapter outlines the challenge of integrating of biological and clinical markers of aging.
Biomarkers of Human Aging is written for professionals and practitioners engaged in the study of aging, and will be useful to both advanced students and researchers.
Chapter 1: Introduction - Alexey Moskalev
Section-1: BIOMARKERS OF AGING AND HEALTH
Chapter 2: Practical Detection of Biological Age: Why it is not a trivial task - Ancha Baranova Tiange Cui,
Boris Veytsman
Chapter 3: Biological age is a universal marker of aging, stress, and frailty - Timothy
V. Pyrkov, Peter O. Fedichev
Chapter 4: Biomarkers of health and healthy ageing from the outside-in
- Jonathan Sholl , Suresh Rattan
Chapter 5: Biomarkers of aging - Yizhen Yan, Yonglin Mu, Weiyang
Chen, Jing-Dong J. Han
Chapter 6: Review of molecular and cellular biomarkers of aging - Ilya Solovyev,
Mikhail Shaposhnikov, Alexey Moskalev
Section-2: PROTEOMICS AND GLYCOMICS BIOMARKERS OF AGING
Chapter 7: IgG glycans as a biomarker of biological age - Vilaj M, Gudelj I, Trbojevic-Akmacic I, Lauc G, Pezer
M
Chapter 8: Oxidatively modified proteins and maintenance systems as biomarkers of aging - Bertrand
Friguet, Martin Baraibar
Chapter 9: Is impaired proteodynamics a key to understand the biomarkers
of cellular aging? - Jacek M. Witkowski ,Tamas Fulop
Section-3: GENETICS AND EPIGENETICS
AGING MARKERS
Chapter 10: Genetic markers of extreme human longevity - Paola Sebastiani, Anastasia
Gurinovich, Harold Bae, Thomas T Perls
Chapter 11: Epigenetic biomarkers of aging - Morgan E. Levine
Chapter 12: DNA methylation biomarkers to assess biological age -Dmitiriy Podolskiy, Vadim Gladyshev
Chapter 13: Epigenetics of brain aging: lessons from chemo brain and tumor brain - Anna Kovalchuk,
Bryan Kolb, Olga Kovalchuk
Chapter 14: Approaches and methods for variant analysis in a cell - Alexej
Abyzov, Flora M. Vaccarino, Alexander E. Urban, Vivekananda Sarangi
Section-4: IMMUNOSENESCENCE AND
INFLAMMAGING MARKERS
Chapter 15: Is there any reliable biomarker for immunosenescence and inflammaging?
- Tamas Fulop, Alan Cohen, Glenn Wong, Jacek M Witkowski, Anis Larbi.
Chapter 16: Immune parameters
associated with mortality in longitudinal studies of very old people can be markedly dissimilar even in apparently similar
populations - Graham Pawelec, David Goldeck
Chapter 17: Gut microbiota and aging - Kashtanova DA,
Tkacheva ON, Strazhesko ID, Dudinskaya EN, Kotovskaya YuV, Popenko AS, Tyaht AV, Alexeev DG
Section-5:
SYSTEMS BIOLOGY OF AGING, BIOLOGICAL AGE AND MORTALITY MARKERS
Chapter 18: Deep integrated bi