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Hematopoietic Stem Cell Transplantation and Cellular Therapies for Autoimmune Diseases

Richard K. Burt (Redaktør) ; Dominique Farge (Redaktør) ; Milton A. Ruiz (Redaktør) ; Riccardo Saccardi (Redaktør) ; John A. Snowden (Redaktør)

This book summarizes the global progress in medical and scientific research toward converting traditionally chronic autoimmune diseases into a drug-free reversible illness using hematopoietic stem cell transplantation (HSCT) and other cellular therapies such as T regulatory cells (Treg), mesenchymal stromal/stem cells, and chimeric antigen receptor T (CAR T) cells in order to reintroduce sustained immune tolerance. Les mer
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Legg i
Vår pris: 2869,-

(Innbundet) Fri frakt!
Leveringstid: Sendes innen 21 dager

This book summarizes the global progress in medical and scientific research toward converting traditionally chronic autoimmune diseases into a drug-free reversible illness using hematopoietic stem cell transplantation (HSCT) and other cellular therapies such as T regulatory cells (Treg), mesenchymal stromal/stem cells, and chimeric antigen receptor T (CAR T) cells in order to reintroduce sustained immune tolerance. This title provides information on different types of stem cells and immune cells; post-transplant immune regeneration; cellular regulatory requirements; ethical and economic considerations; and the advantages and disadvantages of HSCT in the treatment of a variety of autoimmune diseases versus current conventional treatments. Arranged by disease, the text provides a comprehensive guide to HSCT for all types of autoimmune/immune disorders including monogenetic autoimmune diseases; autoimmune aplastic anemia; neurologic immune diseases including multiple sclerosis, chronic inflammatory demyelinating polyneuropathy, neuromyelitis optica, and stiff person syndrome; rheumatologic diseases such as systemic sclerosis and systemic lupus erythematosus; dermatologic diseases such as pemphigus; gastrointestinal disorders such as Crohn's disease and celiac disease; and immune-mediated endocrinologic disease type I diabetes mellitus. Guidance is provided on the transplantation technique, cell collection and processing, conditioning regimens, infections, and early and late complications.


Key Features








Outlines therapies and techniques for HSCT for autoimmune diseases







Discusses the advantages of HSCT over conventional therapies







Reviews the entire process of stem cell therapy from harvest and ethics to indications, efficacy, and regulatory oversight
FAKTA
Utgitt:
Forlag: CRC Press
Innbinding: Innbundet
Språk: Engelsk
Sider: 666
ISBN: 9781138558557
Format: 28 x 21 cm
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able of Contents


Section 1- Biology of Immune Cells
Ch 1 B cells in aging, age-associated diseases and stem cell transplantation
Daniela Frasca, Maria Romero


Ch 2 T cell biology: changes with disease, aging, and hematopoietic stem cell transplantation
Valquiria Bueno


Ch 3 Plasma cells in autoimmunity
Falk Hiepe, Tobias Alexander, and Andreas Radbruch


Ch 4 CAR T cells for Autoimmunity
Michael C. Milone


Ch 5 Regulatory T cells for the treatment of autoimmune diseases
Claudia Selck and Margarita Dominguez-Villar


Ch 6 Mesenchymal Stromal Cells Derived Extracellular Vesicles
Ines Colmegna and Janusz Rak


Section 2 - Biology of Stem Cells


Ch 7 Induced Pluripotent Stem Cells: the story of genetic reprogramming
Richard K Burt


Ch 8 Mesenchymal stromal cell biology and clinical application
Severine Loisel & Karin Tarte


Ch 9 Neural Stem Cell Biology
Angela Genchi, Beatrice von Wunster, Paola Panina-Bordignon and Gianvito Martino


Ch 10 Hematopoietic stem cells: Hierarchical versus Continuum
Peter Quesenberry, Sicheng Wen, Laura Goldberg and Mark Dooner


Ch 11 Biology of Umbilical Cord Blood Cells
Gesine Kogler and Stefanie Liedtke


Section 3 - Regulatory requirements
Ch 12 Quality, Accreditation, and Regulation in HSCT and Cellular Therapy for Autoimmune Diseases
Eoin McGrath, Joseph Schwartz, Phyllis I. Warkentin, Riccardo Saccardi, John A. Snowden


Ch 13 EUROPEAN PERSPECTIVE ON CELLULAR THERAPY: GOOD TISSUE PRACTICE (GTP) VERSUS GOOD MANUFACTURING PRACTICE (GMP).
Elodie Kerjean, Bechara Mfarrej, & Christian Chabannon


Ch 14 GMP Facility Requirements in the United States of America
Cheryl Stratton and Ann LeFever


Section 4 - Mesenchymal Stem Cells for Immune Diseases


Ch 15 Mesenchymal stromal cell therapy for acute graft versus host disease - from bench to clinical approval
Erik Boberg and Katarina Le Blanc


Ch 16 Adipose-Derived Stem Cells for Systemic Sclerosis Digital Ulcers
Nicoletta Del Papa, Antonina Minniti, Francesca Pignataro, Wanda Maglione and Roberto F. Caporali


Ch 17 Musculoskeletal stromal/progenitor cells-based cell therapy for Rheumatoid Arthritis (RA)
Yves-Marie PERS, Dominique Farge and Christian Jorgensen


Ch 18 Mesenchymal Stromal cells for Systemic Sclerosis
Dominique Farge


Ch 19 Mesenchymal stem cells (MSC) for systemic lupus erythematosus (SLE)
Lingyun Sun and Xinran Yuan


Ch 20 Mesenchymal stem/stromal cells for multiple sclerosis and other neurological diseases
Antonio Uccelli, Tiziana Vigo and Alice Laroni


Ch 21 Mesenchymal stromal cells for perianal fistulizing crohn's disease
Antonio Giordano and Julian Panes


Ch 22 Umbilical Cord Blood or Mesenchymal Stromal Cells as Potential Therapies for Autism Spectrum Disorder
Jessica M. Sun and Joanne Kurtzberg


Section 5 - General concepts: HSCT for Autoimmune Diseases


Ch 23 Animal models of bone marrow transplantation for autoimmune diseases
Yasushi Adachi, Ming Li, Richard K. Burt, Naoki Hosaka, Susumu Ikehara


Ch 24 Autologous HSCT conditioning regimens for autoimmune diseases
Richard K Burt, Dominique Farge, Riccardo Saccardi, Kathleen Quigley, Xiaoqiang Han and John A. Snowden


Ch 25 Immune reconstitution after hematopoietic stem cell transplantation in autoimmune disease
Paolo A. Muraro and Maria T. Cencion


Ch 26 Microbiota and immune response
Ernst Holler, Hendrik Poeck, and Daniela Weber


Ch 27 Infectious complications in patients undergoing HSCT for autoimmune diseases.
Richard K Burt and Dominique Farge


Ch 28 Early Toxicity and Supportive Care of HSCT for Autoimmune Diseases
John A Snowden, Azza Ismail, Richard K Burt, Helen Jessop


Ch 29 Late toxicity and supportive care of patients undergoing haematopoietic cell transplantation for autoimmune diseases
Nina Salooja, Richard K Burt and John A. Snowden


Ch 30 Transfusion Medicine
Khaled El-Ghariani


Ch 31 International Registries Sites / Indications / Activity for HSCT in Autoimmune Diseases: the European Society for Blood and Marrow Transplantation (EBMT) and Center for International Blood and Marrow Transplant Research (CIBMTR)
John A. Snowden, Raffaella Greco, Manuela Badoglio, Myriam Labopin, Omar F. Davila Alvelo and Marcelo C. Pasquini


Ch 32 Hematopoietic stem cell mobilization, collection, apheresis, and harvest procedures
Emilian Snarski and Richard K Burt



Section 6 - Allogeneic HSCT for Autoimmune disease
Ch 33 Hematopoietic Stem Cell Donor Registries: Search Strategies and HLA Methodologies
Catherine Stavropoulos-Giokas, Vasiliki Gkioka and Dominique Charron


Ch 34 Allogeneic HSCT and Graft-versus-Host Disease (GvHD): general principles with reference to autoimmune diseases
Jose Ros-Soto, Richard K Burt and John A. Snowden


Ch 35 Haematopoietic cell transplantation in monogenic autoimmune diseases
Su Han Lum, Emilie P Buddingh, Mary A Slatter and Arjan C Lankester


Ch 36 Advances In The Pathogenesis And Treatment Of Immune Mediated Aplastic Anemia
Shinji Nakao, Sabrina Giammarco and Andrea Bacigalupo


Section 7- HSCT for autoimmune disease Multiple Sclerosis


Ch 37 Magnetic Resonance Imaging in Multiple Sclerosis
Flavia Nelson


Ch 38 Multiple Sclerosis
Azza Ismail, Richard K Burt, Joachim Burman, Basil Sharrack


Ch 39 Disease-modifying therapies and supportive care of multiple sclerosis
Edith Graham, Eileah Loda, and Roumen Balabano


Ch 40 Autologous hematopoietic stem cell transplantation for Secondary Progressive Multiple Sclerosis
Richard K Burt, Basil Sharrack, Roumen Balabanov, John Rose, Xiaoqiang Han, Kathleen Quigley and Riccardo Saccardi


Ch 41 Autologous hematopoietic stem cell transplantation for Relapsing Remitting Multiple Sclerosis
Richard K Burt, Basil Sharack, Joachim Burman, Flavia Nelson, John Rose, Xiaoqiang Han, Kathleen Quigley and Riccardo Saccardi


Ch 42 Immune mechanisms of autologous hematopoietic stem cell transplantation for multiple sclerosis
Joachim Burman



Chronic Inflammatory Demyelinating Polyradiculoneuropathy


Ch 43 Basics and interpretation of electrodiagnostic testing
Hamza Malek


Ch 44 Diagnosis and Differentiation of CIDP from other peripheral polyneuropathies
Celine Labeyrie Fanny Urbain and Cristina Castilla Llorente


Ch 45 Hematopoietic stem cell transplantation for chronic inflammatory demyelinating polyradiculoneuropathy
Gavin Brittain, Richard K Burt, Basil Sharrack


Neuromyelitis Optica


Ch 46 Autologous and Allogeneic HSCT for AQP4-IgG positive Neuromyelitis Optica Spectrum Disorders
Raffaella Greco, Shailee Shah, Sean J Pittock and Richard K Burt



Systemic Sclerosis


Ch 47 Systemic Sclerosis
Katja Lakota, Katja Perdan Pirkmajer and John Varga


Ch 48 The Systemic Sclerosis Heart
Sanjiv J. Shah


Ch 49 Scleroderma Renal Crisis with special considerations for Autologous Hematopoietic Stem Cell Transplant
Marie Hudson, Harold L. Atkins and Cybele Ghossein


Ch 50 Systemic Sclerosis and the Lung
David G Kiely and Robin Condliffe


Ch 51 AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION IN SYSTEMIC SCLEROSIS
Dominique Farge, Zora Marjanovic, Richard K Burt


Crohn Disease
Ch 52 Crohn's Disease: Incidence, Diagnosis, Standard Treatment, Prognosis, Outcome Measures
Gabriel Marcellier MD, Xavier Treton


Ch 53 Hematopoietic Stem cell transplantation an alternative to treat Crohn's disease
Milton Artur Ruiz, Montserrat Rovira, Elena Ricart, Roberto Luiz Kaiser Junior, Richard K Burt


Type I Diabetes Mellitus


Ch 54 Hematopoietic Stem Cell Transplantation for Type I Diabetes Mellitus
Carlos Eduardo Couri and Maria Carolina Oliveira


Systemic Lupus Erythematosus


Ch 55 Hematopoietic stem cell transplantation for systemic lupus erythematosus (SLE)
Tobias Alexander, Renate Arnold, Falk Hiepe, and Richard K Burt


Celiac Disease


Ch 56 Hematopoietic Stem Cell Transplantation for Refractory Celiac Disease type II
Abdulbaqi Al-Toma


Section 8 - Developing indications for HSCT


Ch 57 Haematopoietic stem cell transplantation for Juvenile Idiopathic Arthritis
Mario Abinun, Su Han Lum, Arina Lazareva, Paul Veys, Mary A Slatter


Ch 58 Haematopoietic Stem Cell Transplantation for Rheumatoid Arthritis
Ross Penglase, Robert D Sandler, John Moore and John A. Snowden


Ch 59 Hematopoietic Stem Cell Transplantation for Behcet's Syndrome
Leandro Lara do Prado, Lilian Piron-Ruiz, Milton A. Ruiz, and Celio Roberto Goncalves


Ch 60 Hematopoietic Stem Cell Transplantation and Myasthenia Gravis
Osman Radhwi and Harold Atkins


Ch 61 Autologous Haematopoietic Stem Cell Transplantation in Stiff Person Spectrum Disorder
Zeid Yasiry, Richard K Burt, Basil Sharrack


Ch 62 Hematopoietic Stem Cell Transplant-Based Treatment for Psychiatric Disorders
Sophia Chaudry and Sander Markx


Ch 63 Hematopoietic Stem Cell Transplantation for Psoriasis and Pemphigus Vulgaris


Floyd Silva, John Durkin and Leslie Andritsos


Section 9 - Ethics and economics


Ch 64 Health Economics of Multiple Sclerosis
Daniel M. Hartung


Ch 65 Ethics of Stem Cells and Stem Cell Transplantation for Autoimmune diseases
Kevin FitzGerald SJ


Ch 66 Is Healthcare a Human Right?
Lawrence J. Metzger


Ch 67 Appendices
Indira Arnautovic and Kathleen Quigley
Richard K. Burt, MD (www.astemcelljourney.com) is Fulbright Scholar and Professor of Medicine at Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA, and the first Autoimmune Committee Chairperson for the International Bone Marrow Transplant Registry (IBMTR).





Dominique Farge, MD, PhD is Professor of Internal Medicine at Saint-Louis Hospital, Assistance Publique-Hôpitaux de Paris, (AP-HP), University of Paris, Paris, France; Adjunct Professor at McGill University, Montreal, Canada; and Chairperson of the European Society for Blood and Marrow Transplantation Autoimmune Disease Working Party from 2010 to 2016.


Milton A. Ruiz, MD, PhD is former Professor at the University of São Paulo and the head coordinator of the Hematopoietic Stem Cell Transplant Service of the Beneficência Portuguesa Hospital of São José do Rio Preto, São Paulo, Brazil.





Riccardo Saccardi, MD is Director of Cellular Therapies and Transfusion Medicine Department at Careggi University Hospital in Florence, Italy and Chairperson of the European Society for Blood and Marrow Transplantation Autoimmune Disease Working Party from 2004 to 2010.





John A. Snowden, MD is Consultant Haematologist & Director of Blood and Marrow Transplantation, Department of Haematology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK; Honorary Professor, Department of Oncology & Metabolism, The University of Sheffield, Sheffield, UK; Honorary Clinical Professor, The Cancer Institute, Department of Haematology, University College London, UK; and Chairperson of the European Society for Blood and Marrow Transplantation Autoimmune Disease Working Party from 2016 to 2020.