This proceedings book discusses state-of-the-art research on uncertainty quantification in mechanical engineering, including statistical data concerning the entries and parameters of a system to produce statistical data on the outputs of the system. It is based on papers presented at Uncertainties 2020, a workshop organized on behalf of the Scientific Committee on Uncertainty in Mechanics (Mecanique et Incertain) of the AFM (French Society of Mechanical Sciences), the Scientific Committee on Stochastic Modeling and Uncertainty Quantification of the ABCM (Brazilian Society of Mechanical Sciences) and the SBMAC (Brazilian Society of Applied Mathematics).