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Handbook of In Vivo Chemistry in Mice

From Lab to Living System

Katsunori Tanaka (Redaktør) ; Kenward Vong (Redaktør)

Provides timely, comprehensive coverage of in vivo chemical reactions within live animals





This handbook summarizes the interdisciplinary expertise of both chemists and biologists performing in vivo chemical reactions within live animals. Les mer
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Legg i
Vår pris: 2363,-

(Innbundet) Fri frakt!
Leveringstid: Sendes innen 21 dager
På grunn av Brexit-tilpasninger og tiltak for å begrense covid-19 kan det dessverre oppstå forsinket levering.

Om boka

Provides timely, comprehensive coverage of in vivo chemical reactions within live animals





This handbook summarizes the interdisciplinary expertise of both chemists and biologists performing in vivo chemical reactions within live animals. By comparing and contrasting currently available chemical and biological techniques, it serves not just as a collection of the pioneering work done in animal-based studies, but also as a technical guide to help readers decide which tools are suitable and best for their experimental needs.





The Handbook of In Vivo Chemistry in Mice: From Lab to Living System introduces readers to general information about live animal experiments and detection methods commonly used for these animal models. It focuses on chemistry-based techniques to develop selective in vivo targeting methodologies, as well as strategies for in vivo chemistry and drug release. Topics include: currently available mouse models; biocompatible fluorophores; radionuclides for radiodiagnosis/radiotherapy; live animal imaging techniques such as positron emission tomography (PET) imaging; magnetic resonance imaging (MRI); ultrasound imaging; hybrid imaging; biocompatible chemical reactions; ligand-directed nucleophilic substitution chemistry; biorthogonal prodrug release strategies; and various selective targeting strategies for live animals.





-Completely covers current techniques of in vivo chemistry performed in live animals


-Describes general information about commonly used live animal experiments and detection methods


-Focuses on chemistry-based techniques to develop selective in vivo targeting methodologies, as well as strategies for in vivo chemistry and drug release


-Places emphasis on material properties required for the development of appropriate compounds to be used for imaging and therapeutic purposes in preclinical applications





Handbook of In Vivo Chemistry in Mice: From Lab to Living System will be of great interest to pharmaceutical chemists, life scientists, and organic chemists. It will also appeal to those working in the pharmaceutical and biotechnology industries.

Fakta

Innholdsfortegnelse

1 Summary of Currently Available Mouse Models 1
Ami Ito, Namiko Ito, Kimie Niimi, Takashi Arai, and Eiki Takahashi


1.1 Introduction 1


1.2 Origin and History of Laboratory Mice 2


1.3 Laboratory Mouse Strains 3


1.3.1 Wild-Derived Mice 3


1.3.2 Inbred Mice 4


1.3.3 Hybrid Mice 4


1.3.4 Outbred Stocks 8


1.3.5 Closed Colony 8


1.3.6 Congenic Mice 8


1.4 Mutant Mice 9


1.4.1 Spontaneous 9


1.4.2 Transgenesis 9


1.4.3 Targeted Mutagenesis 11


1.4.4 Inducible Mutagenesis 13


1.4.5 Cre-loxP System 13


1.4.6 CRISPR/Cas9 System 15


1.5 Resources of Laboratory Strains 16


1.6 Germ-Free Mice 16


1.7 Gnotobiotic Mice 18


1.8 Specific Pathogen-Free Mice 18


1.9 Immunocompetent and Immunodeficient Mice 18


1.10 Mouse Health Monitoring 19


1.11 Production and Maintenance of Mouse Colony 19


1.11.1 Production Planning 19


1.11.2 Breeding Systems and Mating Schemes 19


1.12 Mating 21


1.13 Gestation Period 21


1.14 Parturition 21


1.15 Parental Behavior and Rearing Pups 21


1.16 Growth of Pups 22


1.17 Reproductive Lifespan 23


1.18 Record Keeping and Colony Organization 23


1.19 Animal Identification 24


1.20 Animal Models in Preclinical Research 24


References 29


2 General Notes of Chemical Administration to Live Animals 33
Ami Ito, Namiko Ito, Takashi Arai, Eiki Takahashi, and Kimie Niimi


2.1 Introduction 33


2.2 Restraint 34


2.2.1 One-Handed Restraint 34


2.2.2 Two-Handed Restraint 34


2.3 Substances 34


2.3.1 Substance Characteristics 34


2.3.2 Vehicle Characteristics 35


2.3.3 Frequency and Volume of Administration 36


2.3.4 Needle Size 37


2.4 Anesthesia 37


2.4.1 Inhaled Agents 38


2.4.2 Injectable Agents 38


2.5 Euthanasia 40


2.6 Administration 41


2.6.1 Enteral Administration 42


2.6.1.1 Oral Administration 42


2.6.1.2 Intragastric Administration 42


2.6.2 Paren

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